Interstitial Cystitis is a disease characterized by pelvic pain associated with urinary urgency and frequency resulting in significant impact on quality of life. Lack of consensus on disease etiology, pathophysiology, and on effective treatment modalities has made this condition particularly difficult to treat for clinicians. Conventional treatments for Interstitial Cystitis have often been focused on symptom mitigation and long term outcomes have traditionally been poor.
Dr. Lander has been working since 2010 on using stem cells from your own fat to mitigate interstitial cystitis. Using technology developed in Korea and perfected in California, these autologous (your own) fat stem cells from liposuction are processed in a closed system maintaining strict sterility. The liposuction fat can be divided into its natural components including fat cells and regenerative cells in the form of Stromal Vascular Fraction (SVF). SVF contains adult stem cells and growth factors which are signaling molecules. Once SVF is injected back into the patient, the healing cells seek out the sites of damage and disease and become activated. We have anecdotal and experimental evidence that stem cell therapy is effective in healing and regeneration and seeks out damaged tissues to form healthy new blood vessels, urothelial lining, and smooth muscle. SVF has also shown immuno-modulatory properties and can mitigate auto-immune diseases and interstitial cystitis appears to have some auto-immune features. Processing and deployment of adipose derived stem cells represents a new surgical technology that allows patients to receive their own autologous stem cells in an outpatient setting using local anesthetic.
Dr. Lander, as principal investigator and lead author, recently published a paper (Click Here to View Publication) on the use of SVF for Interstitial Cystitis. This publication is the largest human study to date (109 patients) using cell therapy to treat IC. Data was collected worldwide from 18 different centers to complete the study.
Overall, 71.5% of the patients that they felt better after the SVF treatment and also patients reported significant decreases in overall mean pain scores. Patients also reported significant decreases in mean PUF and O’Leary-Sant symptom and bother scores at 1 year. In view of the lack of long term data, it is difficult to draw conclusions regarding the use of autologous SVF containing stem cells with Interstitial Cystitis but the safety and efficacy results of this form of personalized stem cell therapy are promising.
Dr. Lander is the Co-Medical Director of California Stem Cell Treatment Center® and the Cell Surgical Network™ which is an international research collaboration dedicated to the investigational use of adult mesenchymal stem cells found in fat tissue. The goal of the project is to use regenerative cells from one’s own body to provide relief for patients suffering from certain chronic degenerative diseases that have been resistant to common modalities of treatment such as Interstitial Cystitis.